Niacinamide: What Concentration Bands Actually Show Up in Trials
Clinical papers often test 4% or 5% niacinamide for pigment and appearance endpoints. What those bands show, and what CIR use tables covered.
Automated monitoring of regulatory registers and journals. Items are labelled as automated until a named member of staff approves them in the admin; that person is then shown as the reviewer.
How this works: the Desk is software. It drafts Index entries, articles and wire items from the registers and journals it monitors. A draft is published only when a named member of staff approves it in the admin; that person is then shown as the reviewer, with the date, on the page. Pages the Desk wrote that have not yet been approved say “Not yet reviewed” and are kept out of search indexes and feeds.
Clinical papers often test 4% or 5% niacinamide for pigment and appearance endpoints. What those bands show, and what CIR use tables covered.
Two ways to keep water-based skincare free of microbes. We map what safety reviews and lab studies show, and why the finished formula matters.
Three vitamin A relatives with very different evidence behind them. We map what studies show for ageing skin and acne, and how each is regulated.
A US panel's October packet revisits nail-gel photoinitiators. What they do, how salon and at-home use differ, and what under review means.
US safety reviewers are examining six crosslinked hyaluronic acid salts used in serums. How they differ from regular HA, and what the draft report covers.
The US medicines regulator is taking two legacy UV filters off the over-the-counter sunscreen list after deciding the safety case no longer supports everyday shelf use. The order was issued on 10 September 2026 and cannot take effect for at least a year. Shoppers do not need to throw anything out; most bottles never used them.
Bee resin shows up in soothing creams and “repair” serums, but a new Cosmetic Ingredient Review memo says the hard part is matching the science to the exact ingredients on the label. The panel meets in early October to decide how to proceed.
A US cosmetic safety panel is one meeting away from closing an amended review of four gallate antioxidants used to keep formulas stable. The draft still says safe when products are made not to irritate or sensitise.
Europe capped kojic acid at 1% for face and hand leave-ons after a safety review. Canada's Cosmetic Ingredient Hotlist still has no entry for it.
Human stratum corneum barrier function depends on a highly organised intercellular lipid matrix. Peer-reviewed barrier reviews describe…
Emollient esters are why many "weightless" moisturisers still spread. CIR’s amended alkyl esters assessment reviews a broad ester family…
Many modern gels stack Glycerin (glycerin), Hyaluronic Acid (hyaluronic acid / sodium hyaluronate family), and Panthenol (panthenol) in one…
The Cosmetic Ingredient Review Expert Panel reviewed Polyacrylate Crosspolymer-6 at its June 15–16, 2026 meeting and issued an Insufficient…
Ahead of its 5–6 October 2026 meeting, CIR circulated a strategy memo on four propolis-derived cosmetic ingredients: propolis extract,…
CIR posted a revised Draft Tentative Report on 11 September 2026 covering ethyl tafluprostamide and isopropyl cloprostenate — synthetic…
The Expert Panel for Cosmetic Ingredient Safety posted a Draft Report on 11 September 2026 covering six crosslinked hyaluronate…
CIR released a Draft Tentative Report on 11 September 2026 for three acylphosphine oxide photoinitiators used mainly in UV-cured nail…
The Scientific Committee on Consumer Safety (SCCS) has concluded that acetophenone (CAS 98-86-2) is safe for use in finished cosmetic…
FDA has finalised the removal. On 11 September 2026 the agency published notice of final administrative order OTC000008-1, striking PABA…
CIR’s kojic acid re-review is back on the table. On 11 September 2026 the Expert Panel released a Draft Tentative Amended Report for the…
The antioxidant quartet is nearly closed. CIR released a Draft Final Amended Report on alkyl gallates on 11 September 2026—covering propyl…
The United States has its first new sunscreen filter in decades. Final administrative order OTC000039 adds bemotrizinol (BEMT) to OTC…