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Tuesday, October 13, 2026Index last updated Oct 9
The Index  ·  Hydrocarbon occlusive

Petrolatum

Petrolatum

Classic occlusive that slows TEWL and accelerates barrier recovery after disruption; FDA OTC skin protectant.

StrongDecades of barrier physiology and OTC protectant status; cosmetic purity specs matter.
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Written byTheSkindex Desk
Reviewed byNot yet reviewed
Last updated18 Sept 2026
Sources3 cited

Petrolatum is a purified mixture of hydrocarbons used as an occlusive film-former. In disrupted skin it markedly reduces transepidermal water loss and speeds recovery of barrier function compared with untreated sites[1].

What it does

By forming a water-impermeable film it keeps endogenous water in the stratum corneum while lipids reorganise. That is why it anchors repair creams (including ceramide systems such as ceramide NP) and why the FDA lists white petrolatum as an OTC skin protectant[2].

The evidence

Classic barrier-disruption work showed petrolatum-treated sites recovered faster than untreated controls[1]. CIR has assessed petrolatum as safe in cosmetic use when polycyclic aromatic hydrocarbon specifications are met[3].

How to use it

Best as the outer layer on dry or compromised skin, or mid-formula in creams. Cosmetically heavy; lighter silicones such as dimethicone are often preferred for daytime face use.

Evidence by claim

Graded separately; the entry grade is the best-supported claim
Reduces TEWL and accelerates barrier recovery after disruption[1]
Strong
Recognized OTC skin protectant (white petrolatum)[2]
Strong

Safety & limits

Source and region, always
skin protectant — White petrolatum is an FDA OTC skin protectant active when monograph conditions are met.[2] US
all — CIR: safe as used in cosmetics when PAH impurity specifications are met.[3] CA US EU UK

Sources · 3

Numbered as cited in the text
  1. [1]Ghadially R, Halkier-Sorensen L, Elias PM. Effects of petrolatum on stratum corneum structure and function. Journal of the American Academy of Dermatology (1992)doi:10.1016/0190-9622(92)70053-I
  2. [2]FDA. Skin Protectant Drug Products for Over-the-Counter Human Use; Final Monograph. Federal Register / 21 CFR 347 (2003)regulator
  3. [3]Cosmetic Ingredient Review. Final Report on the Safety Assessment of Petrolatum. Journal of the American College of Toxicology (1984)regulator

Revision history

18 Sept 2026Drafted by botTheSkindex Desk