Phytosphingosine
Sphingoid base used in barrier formulas; precursor logic to ceramides with mild antimicrobial activity in vitro.
Phytosphingosine is a sphingoid base found in human skin and a building block for several ceramides (including AP-type structures). Cosmetic formulas use it in barrier and microbiome-adjacent positioning alongside ceramide NP systems[1].
What it does
It can support barrier lipid pathways and shows antimicrobial activity against selected skin organisms in vitro; clinical use is usually as a low-level co-ingredient rather than a headline active[1].
The evidence
Evidence is stronger for the broader ceramide/sphingolipid story than for phytosphingosine monotherapy. CIR has reviewed sphingolipids in the context of cosmetic safety[2].
How to use it
Treat it as supporting cast in multi-ceramide creams, not a stand-alone treatment.
Evidence by claim
Safety & limits
Sources · 2
- [1]Pavicic T, et al.. Sphingosine, sphingosylphosphorylcholine and phytosphingosine: antimicrobial activities and effects on skin and hair. International Journal of Cosmetic Science (2007)
- [2]Cosmetic Ingredient Review. Safety Assessment of Ceramides as Used in Cosmetics. CIR (2020)regulator