Panthenol

Panthenol is the alcohol precursor of pantothenic acid (vitamin B5), a component of coenzyme A. Topically it behaves as a humectant and, once converted in skin, supports lipid synthesis and keratinocyte proliferation[1].

The evidence

In a controlled study of surfactant-irritated skin, 5 % dexpanthenol accelerated barrier recovery and reduced inflammation versus vehicle[2]. Clinical reviews support its use for post-procedure care, mild irritation and dryness[1].

It is a reliable supporting player rather than a headline active. Pairs with niacinamideNiacinamideStrongNiacinamide · Vitamin B3 amideWater-soluble B3 with strong evidence for barrier, tone and sebum; among the most studied topical actives.Open in the Index → and centella asiaticaCentella asiaticaLimitedCentella Asiatica Extract · Botanical extract (triterpenoids: asiaticoside, madecassoside)Soothing botanical with decent wound-healing data; cosmetic evidence is mostly extrapolated from its triterpenes.Open in the Index → in barrier-focused routines.